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Aug 14

Research Bit: Enhanced insulin signaling ameliorates C9orf72 repeat toxicity in Drosophila

Research Bits
The Packard Center welcomed Adrian Isaacs, PHD from University College London to a recent Investigator's meeting.

Date: August 14, 2020

Presenter: Adrian Isaacs, PhD

Talk Title: Enhanced insulin signaling ameliorates C9orf72 repeat toxicity in Drosophila

What was the question being asked?

How is reduced insulin signaling in diseased neurons contributing to their degeneration?

Why is this important for ALS research?

Issues with glucose metabolism are commonly reported in patients with ALS. This study provides some understanding as to how insulin signaling can be artificially increased in order to restore the health of neurons in a fruit fly model of ALS.

What was the take-home message?

By increasing the amount of insulin signaling receptors in a C9ORF72 ALS fruit fly model, they were able to reduce various forms of degeneration that typically occur as a result of the mutation.

How do you think the results of this study might impact future approaches to the treatment of ALS?

This work represents a step forward in our understanding of how insulin signaling relates to neurodegeneration. The significance of this lies in the abundance of existing drugs that target insulin signaling, which may expedite their potential use in future ALS studies.

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