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Sep 11
2020

Research Bit: Programmed axon death and its roles in disease

Research Bits
The Packard Center welcomed Michael Coleman from the University of Cambridge and Ahmet Hoke from Johns Hopkins University to a recent Investigator's meeting

Meeting Date: September 11, 2020

Presenter: Michael Coleman and Ahmet Hoke

Talk Title: Programmed axon death and its roles in disease

What was the question being asked?

The Coleman and Hoke labs are working to understand the molecular mechanisms underlying axon death and the role axon death plays in multiple neurological diseases including ALS.

Why is this important for ALS research?

Axonal deterioration is a prominent feature of multiple neurological diseases. Understanding the underlying biology of this pathological phenomenon is likely to provide novel insights into potential therapeutic strategies for disease.

What was the take-home message?

Programmed axon death contributes to the pathogenesis of multiple neurological diseases, including ALS. Blocking this process would help to limit neuronal death and disease progression.

How do you think the results of this study might impact future approaches to the treatment of ALS?

These studies provide additional mechanistic insights into potential targets for therapeutic intervention in neurological disease.

 

Prepared by:

Alyssa Coyne, PhD
Rothstein Lab
Johns Hopkins University

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