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Research Bytes

Jun 14
2021
ALS Headlines, Packard Center News, Research Bytes
A team of Packard-funded scientists, led by Udai Pandey and Chris Donnelly at the University of Pittsburgh, have identified a new mechanism through which mutant FUS can lead to ALS
Nov 9
2020
Packard Center News, Research Bytes
In a new study, Packard researcher Jiou Wang and colleagues have identified a new regulatory switch for protein quality control that plays a role in the development of ALS.
Click here to read the full study:
Jul 23
2020
Research Bytes
Packard scientist Mervyn Monteiro showed that ALS-linked mutations in UBQLN2 interferes with autophagy by blocking an acidification step critical for the process.
Jul 9
2020
Packard Center News, Research Bytes
In a new study, Packard scientist Jiou Wang and colleagues showed that RNA structures called G-quadruplexes play a role in the formation and function of a type of granule called a paraspeckle.
Click here to read the full study:
Apr 22
2020
Research Bytes
In a new paper in PLOS Genetics, Packard researcher Jiou Wang identified a new mechanism through which C9orf72 may cause disease.
Click here to read the full paper in PLOS Genetics...
May 23
2019
Research Bytes
 A recent study by Packard Center Investigator Fen-Biao Gao describes a new and innovative mouse model of ALS-FTD that uncovers a novel mechanism as to how the disease degeneration progresses.
May 14
2019
Research Bytes
A new report identifies a set of new regulators of cellular quality control that is critical for proteins related to ALS and frontotemporal dementia (FTD).
May 8
2019
Research Bytes
A new research study offers profound insight as to why this diminishing response to treatment occurs.
Apr 18
2019
Packard Center News, Research Bytes
Innovative new research from Packard investigators explores how RNA binding proteins might lead to ALS.
Apr 10
2019
Research Bytes
Packard researchers at the Barrow Neurological Institute uncover a novel function of the C9orf72 mutation, delivering invaluable insight into the pathogenesis of ALS