Research Bytes
Nov 9
2021
Researchers identify how the repeat sequence at the front of C9ORF72, a gene closely associated with ALS, can create toxins in the cell that lead to disease.
Nov 9
2021
Researchers identify how C9orf72 triggers inflammation and age-dependent neural defects that affect learning and memory.
Jun 14
2021
A team of Packard-funded scientists, led by Udai Pandey and Chris Donnelly at the University of Pittsburgh, have identified a new mechanism through which mutant FUS can lead to ALS
Nov 9
2020
In a new study, Packard researcher Jiou Wang and colleagues have identified a new regulatory switch for protein quality control that plays a role in the development of ALS.
Click here to read the full study:
Jul 23
2020
Packard scientist Mervyn Monteiro showed that ALS-linked mutations in UBQLN2 interferes with autophagy by blocking an acidification step critical for the process.
Jul 9
2020
In a new study, Packard scientist Jiou Wang and colleagues showed that RNA structures called G-quadruplexes play a role in the formation and function of a type of granule called a paraspeckle.
Click here to read the full study:
Apr 22
2020
In a new paper in PLOS Genetics, Packard researcher Jiou Wang identified a new mechanism through which C9orf72 may cause disease.
Click here to read the full paper in PLOS Genetics...
May 23
2019
A recent study by Packard Center Investigator Fen-Biao Gao describes a new and innovative mouse model of ALS-FTD that uncovers a novel mechanism as to how the disease degeneration progresses.
May 14
2019
A new report identifies a set of new regulators of cellular quality control that is critical for proteins related to ALS and frontotemporal dementia (FTD).
May 8
2019
A new research study offers profound insight as to why this diminishing response to treatment occurs.
