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ALS Alert Newsletter

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Jun 7
2021

Packard Center awards new research grant to study the role of Vps4/ESCRT Complex in Nucleoporin Degradation in C9-AL.

Note: This grant was made possible through a generous gift from the Bruce Edwards Foundation.

The Packard Center is pleased to announce an award to Tom Lloyd, MD, PhD (Johns Hopkins University) to study the role of the Vps4/ESCRT Complex in Nucleoporin Degradation in C9-ALS. The nuclear pore is one of the largest protein complexes in neurons and other cells, and functions as a gateway for signals from the environment to influence DNA in the nucleus. Researchers around the world, many of whom are funded by the Packard Center, suggest that disruptions in the nuclear pore occur early during ALS and contribute to motor neuron degeneration.

Work from the Rothstein and Lloyd Labs has shown that nucleoporins, protein subunits that make up the nuclear pore, are broken down. However, the mechanisms leading to nucleoporin degradation remain unknown. “This Packard Center grant will allow us to use the genetic power of fruit flies to perform a genetic screen that will hopefully gain insight into how nucleoporins are degraded in fly models of ALS in hopes of identifying novel treatment targets,” noted Lloyd. “We are proud of our continued partnership with the Packard Center.”

This project was funded through a grant from The Bruce Edwards Foundation.