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ALS Alert Newsletter

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Oct 28
2021

Packard Center awards new research grant to study the regulation of TDP-43 nuclear localization

The Packard Center has awarded a research grant to Lindsey Hayes, MD, PhD for a project entitled: regulation of TDP-43 nuclear localization

The Packard Center is pleased to announce a grant to Lindsey Hayes, MD, PhD of Johns Hopkins University to study the regulation of TDP-43 nuclear localization.

Despite the remarkable diversity among ALS patients, disease presentations, and genetic mutations, over 97% of ALS cases show mislocalization of TDP-43, an essential protein for RNA processing and stability. Abundant evidence links disruption of TDP-43 to the pathogenesis of ALS, but the cause of TDP-43 mislocalization in disease remains unknown. Dr. Hayes’ goal is to identify key factors that regulate TDP-43 localization within cells, to better understand what causes TDP-43 mislocalization in ALS and develop novel therapeutic strategies targeting this pathology.