Peter Todd, MD, PhD
The Integrated Stress Response in ALS
Our research explores the intersection of the integrated stress response with the mechanisms that lead to Amyotrophic Lateral Sclerosis. The stress response is triggered by many different cellular pathways and its activation triggers global changes in the way proteins are made and the distribution of proteins which bind to RNA. We will study this process in the context of the most common genetic cause of ALS, the hexanucleotide repeat expansion in C9orf72, with a goal of identifying novel pathways that might be targeted therapeutically in ALS and related neurodegenerative disorders.
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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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