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Sami Barmada, MD, PhD

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Sami Barmada, MD, PhD

University of Michigan

Mechanisms of initiation and progression in ALS

Motor neurons control all of our movements from walking to breathing. These cells are selectively hit early in ALS, but why motor neurons are so susceptible remains mysterious. Our goals are to (1) determine what makes motor neurons vulnerable in ALS, and (2) define how ALS spreads from neuron to neuron. With this knowledge, we will develop targeted treatments that prevent the death of motor neurons in ALS and prevent the spread of disease once it has begun.

Note: Funding for this project was made possible by The Boye Foundation


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Steven Finkbeiner

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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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