Thomas Lloyd, MD, PhD
Axonal transport and retrograde signaling in Drosophila models of c9-ALS
This research will use a fruit fly model of ALS caused by a mutation in the C9orf72 gene to understand how alterations to the transport of large molecules across the nucleus and along axons contribute to disease. Specifically, this study will investigate retrograde stress signaling mediated by the JNK pathway to determine if this may be a therapeutic target for C9-ALS.
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Gladstone Institutes, UCSF
Two recently discovered genes that have been associated with both familial and sporadic forms of ALS encode the related proteins TDP43 and FUS cause neuron death in ALS.
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